A new Israeli study finds that those who ingest significant amounts of artificial sweeteners may be setting themselves up for glucose intolerance. Glucose is the most significant simple sugar in our metabolism. Investigators at the Weizman Institute of Science made this discovery. Other negative effects were caused by a high intake of artificial sweeteners including an increased risk of vascular disease and bladder cancer. It was also found to increase appetite, not something someone ingesting a diet soda wants to hear. A previous study out of the same institute found that artificial sweeteners disrupt gut bacteria which could lead to diabetes and weight gain. Scientists are still uncovering the seemingly vast influence gut bacteria have on the systems of the body, including metabolism and immunity. One such colony of gut bacteria is responsible for metabolizing sugar. The results were come upon while testing laboratory mice for glucose intolerance. Investigators set a baseline in this way.
The mice were then split into three cohorts. The first was given one of three different artificial sweeteners: aspartame, saccharin or Sucralose added to their drinking water. The second had sugar added to their water and the third nothing at all. After 11 weeks, a follow up glucose intolerance test was administered. Investigators were shocked at the result. The cohort that had been given the artificial sweetener had become glucose intolerant. The others were fine, however. Type-2 diabetes often starts out as glucose intolerance. Other tests on mice and other animals found similar results. High intake of these sweeteners causes glucose intolerance. The disappearance of these crucial colonies of gut bacteria in order to metabolize glucose left test subjects intolerant, researchers found. Investigators found that whether obese or thin the results were the same, the subjects became glucose intolerant. Of course, this has not been tested on humans. What’s more, these test subjects were ingesting high levels of these artificial sweeteners. Still, the trend remains. The results are clear, it pays to steer clear of artificial sweeteners and ingest limited amounts for optimum health.